Endocrine Abstracts

Carcinoma-associated fibroblasts (CAFs) within the stromal tumor microenvironment play a key role in promoting the development, progression and therapy resistance of prostate cancer (PCa). However, the stromal compartment is not targeted by current treatment strategies. Elevated secretion of transforming growth factor beta (TGFβ) by epithelial cells in prostate intraepithelial neoplasia (PIN) lesions and tumor cells induces fibroblast activation to the CAF phenotype and i...